main window will allow you to select the serial device you want to program from a drop down menu you can find in the upper right side of the inteface. 

PonyProg's I/O port setup window dialog will allow you to select the type of device you want o program (serial or parallel) and to select the polarity of the control lines. 

PonyProg's Device menu allows the user to load the profile of one of the predefined serial devices in the list.