1. Install Spotipy from the Python Package Index, e.g. using easy_install:

    $ easy_install spotipy
   

2. Remember to activate assistive device support see http://www.macspeech.com/extensions/faq/kb.php?article=48

3. Use Spotipy like so:

    from spotipy import Spotipy
   
    spotify = Spotipy()
    
    # play/pause
    spotify.play_pause()
    
    # next/previous
    spotify.next()
    spotify.previous()
    
    # shuffle
    spotify.shuffle()
    
    # repeat
    spotify.repeat()
    
    # volume up
    spotify.volume_up()
    
    # volume down
    spotify.volume_down()
    
    # mute
    spotify.mute()
   

Inspired by http://macdevcenter.com/pub/a/mac/2007/05/08/using-python-and-applescript-to-get-the-most-out-of-your-mac.html?page=2 and http://www.jacktams.net/2009/05/15/controlling-spotify-through-applescript-quicksilver/