DNA Baser

DNA Baser is an advanced bioinformatics software application specialized in DNA sequence assembly, sequence analysis, contig editing and mutation detection.

When you think about molecular biology programs you automatically link them with a comprehensive and sometimes a crowded interface where you need to dedicate your time in order to get an idea about how the software can be tweaked.

However, this is clearly not the case with DNA Baser. The tool displays a user-friendly layout, embeds tutorials for helping you learn more about its features, gives you quick access to an online help manual, and provides several samples that can be imported in your projects.

When it comes to importing data into your projects, you are allowed to add information from ABI, SCF, FAST, TXT, SEQ, GBK, or CSV file format.

DNA Baser lists all tasks in the main panel, so you can easily proceed with working with sequence processing, namely sequence assembly (single contig assembly or batch assembly based on name pattern or subfolders) or editing and cleaning options (single sequence editing and cleaning or batch sequence cleaning).

If you opt for the mutation detection process, you are given the freedom to apply this particular task in a single chromatogram or through sequence assembly/alignment from a single organism (multiploid with cloning or diploid without cloning) or from different organisms (two or more), such as haploids, multiploids with cloning or diploids without cloning.

There’s support for several post processing options that you can take advantage of, namely sequence dereplicator (if duplicate files are found, you can copy or move them to a custom folder) and reverse complement.

You can make use of batch processing in order to convert various files (e.g. ABI, SCF, FAST, TXT, SEQ) to FASTA file format. When it comes to encoding GBK files to FASTA file format, you are allowed to select the elements that you want to include in the output FASTA file, such as definition, organism, version, gene, and clone.

DNA Baser also features automatic cleaning (trimming) of the bad ends of chromatograms, synchronized display between chromatograms and contig, proprietary algorithm for correction of ambiguous bases, automatic vector removal and metadata integration, as well as chromatogram viewer and editor.

To sum things up, DNA Baser comes with a comprehensive suite of feature and delivers a clean and smart working environment for managing DNA sequence assemblies, and is suitable especially for professional users.