Genomatix ChipInspector

The ChipInspector application was designed to extract significant information right from the expression level of single probes from microarrays.

Sophisticated analysis techniques and state-of-the-art genomic knowledge dramatically increase the number of significant features while simultaneously reducing false positive rates by an order of magnitude. ChipInspector has been shown to deliver useful results even from several years old formalin-fixed paraffin-embedded prostate cancer specimens,

Genomatix offers a single download for BiblioSphere PathwayEdition and ChipInspector. Running the installer will install both applications to your hard disk.

ChipInspector uses the world's largest database of alternative transcripts and promoters to achieve superior signal-noise ratios in microarray analysis. It is unique in removing statistical and gene calling errors right at single probe level. This technology provides the basis for unmatched accuracy in significance analysis of microarray data.

Here are some key features of "ChipInspector":

￭ uses single probe expression levels as input ￭ reduces false positive rates by about an order of magnitude ￭ eliminates normalization/interpolation problems ￭ increases the number of significant features ￭ supports Affymetrix CEL files (other platforms possible) ￭ assigns probes correctly to transcripts and genes ￭ accounts for alternative transcripts ￭ direct transcript view with probe mapping ￭ applies state-of-the-art genomic knowledge ￭ extracts new information by mining previous microarray experiments ￭ results are directly usable as input for BiblioSphere PathwayEdition

Requirements:

￭ Java 1.5.0 or higher ￭ Internet connection ￭ 2 GB main memory (RAM) ￭ 4 GB for tiling arrays ￭ 2 GB available hard disk space