The DNA Melting Simulator #DNA Melting Simulator #Gene to genome #DNA map #DNA Melting #Gene #Genome
MeltSim is a statistical-mechanical program for calculating melting (denaturation) curves (derivative profiles) and maps of DNA, from genes to genomes. The model is the one-dimensional Ising lattice to which loop entropy has been appended.
The original algorithm is that of Poland & Scheraga and Poland, with the Fixman & Friere approximation of the loop entropy by a sum of exponentials. Parameters in Poland's original algorithm were evaluated by Blake & Delcourt and provide near-quantitative agreement between observed and calculated Tm, amplitudes, breadths, and areas of transitions obtained under equilibrium conditions.
The program stores the results of the operation in a log file that allows you to review important information and operations.
System requirements
- Personal Computer with Intel-compatible microprocessor
- 32MB of RAM
- 1MB disk space
MeltSim 1.0
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- Windows All
- file size:
- 510 KB
- filename:
- meltsim-win-1-0b2.zip
- main category:
- Science / CAD
- developer:
- visit homepage
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